Evaluation of topical Dexmedetomidine administration in postlaminectomy epidural fibrosis rat model
نویسندگان
چکیده
منابع مشابه
Topical application of tacrolimus prevents epidural fibrosis in a rat postlaminectomy model: histopathological and ultrastructural analysis.
AIM Postlaminectomy epidural fibrosis is the formation of scar tissue over the dura mater following posterior spinal surgery. This devastating complication is responsible for the substantial amount of failed back syndromes. MATERIAL and METHODS Twenty male Wistar-Albino rats each weighing 350-400 grams were used. Following L3-L5 laminectomy, the rats were randomly divided into 2 g...
متن کاملThe effect of etanercept on spinal epidural fibrosis in a postlaminectomy rat model.
AIM The formation of epidural fibrosis adjacent to the dura mater after posterior spinal surgery is a normal reaction of the body to surgery. Extensive epidural fibrosis is one of the important causes of postlaminectomy syndrome. Etanercept inhibits tumor necrosis factor-alpha and decreases fibroblast migration. Thus, etanercept prevents the formation of fibrosis. The aim of this study was to i...
متن کاملThe effect of bevacizumab on spinal epidural fibrosis in a postlaminectomy rat model.
AIM Spinal epidural fibrosis is an inherent result of surgical trauma after laminectomy. The conditions in which epidural fibrosis is excessive are in the etiology of failed back syndrome. There have been many attempts to prevent formation of epidural fibrosis. Bevacizumab which is an anti-angiogenic medication, inhibits the effect of VEGF and thereby decreases the new blood vessel formation an...
متن کاملPrevention of Epidural Fibrosis Using Ranibizumab in a Postlaminectomy Rat Model.
AIM One of the most significant reasons for persistent low back pain experienced after spinal surgery is epidural fibrosis seen after laminectomy procedures. This study shows the effects of Ranibizumab on spinal epidural fibrosis in the laminectomy area by blocking the effect of vascular endothelial growth factor. MATERIAL AND METHODS Twenty Wistar rats were used in this study. Rats were divi...
متن کاملEvaluation of Topical Application of Polysaccharide Hemostat and Oxidized Regenerated Cellulose on Epidural Fibrosis in Rats
Evaluation of Topical Application of Polysaccharide Hemostat and Oxidized Regenerated Cellulose on Epidural Fibrosis in Rats Ahmet Gurhan GURCAY, Atilla KAZANCI, Oktay GURCAN, Ismail BOZKURT, Evrim ONDER, Faruk ALTINEL, Murad BAVBEK Ankara Ataturk Training and Research Hospital, Neurosurgery, Ankara, Turkey Diskapi Yildirim Beyazit Training and Research Hospital, Pathology, Ankara, Turkey Baske...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Surgery
سال: 2018
ISSN: 1743-9191
DOI: 10.1016/j.ijsu.2018.03.032